Exim: cannot route to sender?

I'm unable to find what is causing this below (any insight please?)

From exim main log:

2002-09-20 19:30:43 17sXEO-0007Yz-00 ** email@domain R=lookuphost T=remote_smtp: SMTP error from remote mailer after RCPT TO:<email@domain>: host domain [x.x.x.x]: 550 cannot route to sender address <nobody@host.server>

The remote server is also Exim. I checked that host.server resolves to the correct IP address. May be this has to do with reverse lookup? I'm not sure.

Exim: cannot route to sender?

 

 

 

 

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