tweak Mysql value

I need to increase key_buffer_size to 64MB instead of 8MB as default size and table_cache to 256. However, after running

safe_mysqld -O key_buffer=64M -O table_cache=256 \
-O sort_buffer=4M -O read_buffer_size=1M &

BUT it remains in effect only for that instance of the server. Is there a way for me to change them permanently? :rolleyes

thanks
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