Spam Spam Spam

Nowadays nearly everyday 2 days I receive a flood of spams sending to my domains in all permutations a to z 1 to 9 atoz1to9@yourname.com resulting in a large number of bounces and queues. These are not from open relays. Every hard to block , it is from everywhere. How to deal with these? Also any good range of class Cs I should block besides those in ordb and spamhaus?

 

 

 

 

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