Limiting E-mail

Is it possible to deny incoming e-mail to a particular address for a particular domain, based solely on the originating e-mail address?

I don't have my heart set on an MTA yet, although I'm leaning towards exim.

For instance, user1@domain.com can send e-mail to sales@mydomain.com, but not support@mydomain.com while user2@domain.com can send e-mail to both sales@mydomain.com and support@mydomain.com

Thanks!

 

 

 

 

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