Why cpanel webmail not working behind ISA server ?

I am facing one problem with cpanel webmail, one person have account of hosting, and he is running ISA server for proxy net sharing in office computers.

He is trying to get access to www.domain.com/webmail , but webmail is not working there, on main server its working, but on proxy client its not working, whats the reason ? site is coming but webmail no.

Thanks

 

 

 

 

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